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Arthro System
Condrostress® H
Supra-additive chondroprotection for joint stress in competition horses |
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Cod. |
Prodotto |
Confezione |
Euro |
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2006 |
Condrostress® H |
360 g |
93,00 |
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Indications
Chondroprotective nutraceutical indicated in all cases of joint stress in the racehorse: intense sporting activity (trotting, galloping and jumping), forced inactivity and post-traumatic rehabilitation, invasive diagnostic procedures and senile chondrodegeneration.
Adjuvant in the treatment of primary DJD and DJD secondary to developmental osteoarticular disorders (DOD), and to articular stress (i.e. hyper- or hypomobility, fractures, articular laxity, orthopedic surgery, traumatic joint injuries), and in the repair of bone fractures and tendon injuries.
Dosage
Horse: 2 measures for 4-6 weeks, 3-4 times a year.
Active constituents per measure (6 g spoon)
glucosamine, 3,000 mg; L(+) ascorbic acid (vit. C), 510 mg; rutin, 348.33 mg; dl-alpha-tocopherol acetate (vit. E), 255 mg; quercetin, 246.67 mg.
Properties
Condrostress®H is a chondroprotector specifically designed for equine DJD. Condrostress®H can be used as an adjuvant approach to orthopedic surgery and symptomatic drugs (non-steroidal anti-inflammatory agents, corticosteroids) in the equine DJD. The product contains glucosamine and an antioxidant complex (quercetin, rutin, ascorbic acid, tocopherol acetate).
Glucosamine is an aminosugar and represents the backbone of GAGs (hyaluronic acid, chondroitin sulfates) of which it stimulates the synthesis. It has a very high absorption rate when orally administrated and has proved to have chondroprotective activity both in vitro and in vivo, in horses too.
Bioflavonoids (quercetin and rutin) are natural antioxidants, which gives to Condrostress®H an extra chondroprotection activity. During the articular inflammation that characterizes equine DJD, oxidation exceeds antioxidant natural body defenses, because Reactive Oxygen-derived Species (ROS) are overproduced by various cell types inside the joint. ROS play a pivotal role in proteoglycan depolimerization, matrix degradation, and finally cartilage destruction (chondrolysis).
Quercetin is a naturally occurring polyphenolic compound of the bioflavonoid class with high strength antioxidant - antinflammatory activity, being able to:
- scavenge ROS,
- protect joint cells from ROS citotoxicity,
- downmodulate inflammatory cells activation and degranulation,
- inhibit proinflammatory cytokines secretion and activity.
Rutin is the glycosilated form of quercetin, whose quercetin conversion is guaranteed by intestinal bacterial microflora. The glycosidase enzyme produced by these cells is able to break the rutinose link, transforming rutin in quercetin.
Ascorbic acid is a natural hydrophilic antioxidant which protects matrix molecules against oxidative damage, particularly collagen fibers. Moreover it is an important flavonoid-sparing/protective.
Tocopherol is a natural lipophilic antioxidant which acts as a lipid peroxide scavenger protecting cell membranes against oxidative stress.
Both ascorbic acid and tocopherol acetate strengthen the bioflavonoid effects and are from them protected and continuously regenerated. It has recently been demonstrated that the association of the two aforementioned vitamins with bioflavonoids possesses a synergistic rather than additive effect.
| Glucosamine HCl |
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Chondroprotection |
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| Bioflavonoids |
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Anti-oxidant |
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| Ascorbic acid |
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Anti-oxidant |
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| Tocopherol |
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Anti-oxidant |
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Materiale informativo
 Depliant (Italian) (2.24 Mb - PDF)
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